They all met at the time appointed, and as the Anilcans were unable to oppose the groat force which came against them, the Guachacoyans entered the town killing all they met, without regard to age or sex; committed all imaginable barbarities, broke open the sepulchres scattering and trampling on the bones, and took away the scalps of their countrymen and other trophies which the Anilcans had hung up in commemoration of their victories. On seeing the barbarity of his allies, Soto sounded a retreat and ordered the Spaniards to turn the Indians out of the town, wishing anxiously to put a stop to any farther mischief, and to prevent it from being set on fire. But all his efforts were ineffectual, as the Guachacoyans thrust burning brands into the thatch of the houses, which soon took fire, and the town was utterly destroyed. The Spaniards and their allies now returned to Guachacoya, where Soto gave orders for cutting down and hewing timber with which to build the brigantines, and to prepare iron work for their construction; designing when the vessels were finished to cross the river into a province named Quiqualtangui, which was very fertile and populous, the cacique of which had a town of five hundred houses, but who could never be induced to listen to proposals of peace from the Spaniards: On the contrary, he had sworn by the sun and moon, that he would give battle to these vagabond robbers, and would hang up their quarters on trees. The general endeavoured to appease him with presents and fair words, being always generous towards the leaders of the barbarians, endeavouring to bear with and soften their savage manners, and to conciliate their friendship. By this wise conduct he had hitherto been able to subsist his troops for so long a time among so many fierce and savage nations.

While engaged in these things, Soto was seized with a violent fever, which increased upon him so that he soon perceived it would prove mortal. He made therefore his will, and endeavoured to prepare for death like a good Christian. That nothing might be left unprovided for, he appointed in presence of all his officers and principal followers Luis Moscoso de Alvarado to succeed him in the command till the king might order otherwise; and after commending the virtue and bravery of Alvarado, he entreated and commanded all to yield him implicit obedience, even taking their oaths to that purpose, and represented to them how necessary it was for them all to be united and obedient, for their own preservation among these barbarous nations. He then took an affectionate leave of all his officers and soldiers, and departed this life on the seventh day of his illness, after performing all the duties of a zealous Christian. Ferdinand de Soto was of a comely appearance and pleasant countenance, and of affable and generous dispositions. He was an excellent soldier, and managed his weapons with much dexterity both on foot and on horseback; skilful and experienced in all military affairs; always brave and cool in action, and the foremost in every enterprise of danger: severe in punishing when necessary, yet easy to forgive, and always inclined to please his soldiers when that might be done without lessening his authority. At his death he was only forty-two years of age, and had expended his whole fortune, exceeding 100,000 ducats on this romantic and fruitless expedition. His death was universally lamented among his followers, as he had acquired their universal love and esteem by his excellent qualities and conduct. It was thought necessary to bury him under night, that his death might not be known to the Indians, nor the place of his interment, lest they should insult his remains; but in spite of all their precautions the secret was revealed; for which reason they hollowed out a log of oak into which they put his body, and sunk it in the middle of the great river, at a place where it was a quarter of a league across and nineteen feet deep.

When the funeral of the general was over, Luis de Alvarado assembled his officers to hold a council upon the present state of their affairs. After thanking them for admitting him as their commander, and making a statement of their numbers, arms, and ammunition, he desired they would determine upon what was best to be done, considering the fierceness and inveterate enmity of the barbarous nations by whom they were surrounded: Whether to prosecute what had been previously resolved upon by their late lamented general, or to devise some other measure for extricating themselves from the country, declaring that he was ready to proceed according to their opinion and advice. In their answer, the officers thanked him for the compliment he paid them, but referred the determination respecting their future proceedings to himself, and again submitted to obey him as their commander. The death of Soto had made a great change in the minds of the Spanish forces, who now determined to abandon the country they had taken so much pains to discover. Accordingly, they set out on the 5th of July 1542, and marched above 100 leagues to the westwards, through a barren and desert country185. On leaving Guachacoya they were joined by an Indian youth of about sixteen years of age, whom they did not observe till the fourth day of their march. Suspecting him of being a spy, Alvarado asked him who he was and what was his object in following them. He said that he had fled from Guachacoya, because the chief whom he served was at the point of death, and he had been appointed to be buried alive along with his master, as it was the custom of the country to inter women and servants along with great personages, to minister to them in the next world.

At the end of the 100 leagues of wilderness, the Spaniards came to a province called Auche, where they were well received, and where they rested for two days. Still determined upon proceeding to the westwards, they were informed that they had a desert wilderness of four days journey to cross, and received a supply of provisions sufficient for the journey, with a guide to conduct them through the wilderness. But after having marched for eight days in that direction, still in the unhospitable and unpeopled wilds, and having been three days without Indian corn, they discovered that they had been imposed upon and were likely to perish of famine. Alvarado now ordered a dog to be let loose upon the faithless guide; who acknowledged that he had received orders from the cacique of Auche to lead them into the heart of the desert that they might there perish, because he did not think himself able to contend with them in arms. He craved pardon therefore of the general for having obeyed the orders of his chief, and engaged to lead the army in three days more, still proceeding to the westwards, to an inhabited country where they would find provisions. But the Spaniards were so incensed against him for leading them into the present alarming situation, that they would not listen to his apology or promises, and permitted the dogs to devour him. Thus left in the utmost want of provisions, and utterly ignorant of the country, the Spaniards held on their way towards the west for other three days, during which they had to subsist upon any wild plants they could find; and at length came to an inhabited though barren country. They here procured the means of subsistence, particularly beef, and saw many fresh cows hides, though the Indians never shewed them any cows186. While the Spaniards were proceeding on their march through this province, which they denominated De los Vaqueros187, or the tribe of cow-herds, they observed an Indian approach from the skirts of a wood, and believing he might have brought some message from the cacique, they permitted him to draw near. But as soon as he was within reach, he levelled an arrow at five or six soldiers who stood together, who fortunately escaped the danger by stepping to a side; but the arrow flew among some Indian women who were dressing provisions for their masters, pierced one of them quite through, and wounded another in the breast, so that both died. On the alarm being given, Baltasar Gallegos, who happened to be at hand, overtook the Indian before he could get back to the wood, and slew him.